La inmunidad a la infección por SARS-CoV-2 dura al menos seis meses

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La inmunidad a la infección por SARS-CoV-2 puede durar al menos seis meses, según un estudio publicado hoy en Nature y realizado con 87 personas que habían sido infectadas por este tipo de coronavirus.

El estudio revela que los niveles de células B de memoria específicas (cuya misión es defender al organismo de futuras agresiones de ese mismo patógeno generando anticuerpos contra el SARS-CoV-2) se mantuvieron constantes durante el período de estudio.

Los resultados sugieren que las personas que han estado previamente infectadas con el SARS-CoV-2 pueden generar una respuesta rápida y eficaz al virus si vuelven a exponerse.

El sistema inmunológico humano responde a la infección produciendo anticuerpos que pueden neutralizar específicamente el agente infeccioso.

Se ha demostrado que los anticuerpos humanos contra el SARS-CoV-2 protegen contra la infección en modelos animales.

Los niveles de estos anticuerpos pueden disminuir con el tiempo, pero las células B de memoria, como su nombre lo sugiere, «recuerdan» el agente infeccioso y pueden incitar al sistema inmunológico a producir los mismos anticuerpos al reinfectarse.

Michel Nussenzweig y sus colegas, de la Rockefeller University de Nueva York (Estados Unidos) evaluaron a 87 personas con un diagnóstico confirmado de COVID-19 a 1,3 y 6,2 meses después de la infección con SARS-CoV-2 y encontraron que aunque la actividad de los anticuerpos neutralizantes disminuye con el tiempo, el número de células B de memoria permanece sin cambios.

Además, los autores observaron que los anticuerpos producidos por estas células son más potentes que los anticuerpos originales, y pueden ser más resistentes a las mutaciones en la proteína del virus que permite la entrada de la célula.

Estas observaciones demuestran que las células de memoria B tienen la capacidad de evolucionar en presencia de pequeñas cantidades de antígeno vírico persistente (pequeñas proteínas del virus que pueden ser detectadas por el sistema inmunológico).

La presencia y evolución continuas de las células de memoria B sugiere que las personas pueden ser capaces de producir rápidamente potentes anticuerpos neutralizantes del virus al reinfectarse con el SARS-CoV-2, concluyen los autores.

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